Psyphon first appears serving Vilgax. When his ship lands on Earth, giving John the Conqueror's challenge, John meets Psyphon and defeats him relatively easily. Though in his next appearance, he proved to be a challenge to Gwen, Kevin, Kai and Yenal, though is swiftly defeated by John again. When he prepares a draining machine to drain Diagon for Vilgax, where he's defeated by Kai and Eunice.
An alternate version of him appears in the dimension of 15.
Psyphon returns, having been recruited into the New Chess Pieces. Vilgax refused to join, and Psyphon betrays him. He appears in the fourth round, being the strongest bishop. He battles Charmcaster in Ledgerdomain, and while he has an advantage with mana absorbing tech, Charmcaster defeats him, and he's lost in Ledgerdomain.
Two alternate dimension versions of him appear, one in the dimension of Rex Forte, and the other in the dimension of Ben 10.
Psyphon makes his main dimension return, as he had become the ruler of Ledgerdomain, his mana absorbing tech repaired. He initiates an attack on Earth. John frees Charmcaster, and working together, they defeat him. He's then thrown into the Null Void.
Afterwards, he is freed from jail by the Intellectuary, becoming his second in command. He has Psyphon lead a team to attack the Clone Temple on Coruscant, and keeps him around with him.
Psyphon is an accomplished alien mobster running out of Las Vegas. When Ryder goes to him, he leads Lt. Steel and SACT to his base of operations. Only Ryder and Psyphon escape, the rest of Psyphon's men and Ester being captured. Psyphon is forced to work with Ryder to free his henchmen from Area 51. He later attacks John, trying to get him to join him to destroy Area 51. John refuses. He then leads an army to attack Area 51, and is thrown into the Null Void.
Psyphon appears in Dimension 0, serving Vilgax who wants the Omnitrix which has fallen to the Earth. He goes down to Earth with GIR, which retrieves the Omnitrix. GIR goes on a rampage with the Omnitrix, defeating Psyphon.
