- Marcus Jones - Voiced by Yuri Lownethal
- Jenna Jones - Voiced by Tara Strong
- David "Davy" Jones - Voiced by Kevin Conroy
- Tessa Waters - Voiced by Laura Bailey
- Vulkan - Voiced by Mark Hamill
- Agent Cane - Voiced by Troy Baker
- Cilhara - Voiced by Laura Bailey
- Enrich Graves/Moonlight - Voiced by Greg Cipes
- Negative Marcus - Voiced by Yuri Lowenthal
- Sesphilios - Voiced by John DiMaggio
- Nancy Jackson - Voiced by Grey DeLisle
- Colonel Phil Derrickson - Voiced by J.K. Simmons
- William Jeffries - Voiced by Nolan North
- Morgan Kingsley - Voiced by Tia Texada
- Time Master - Voiced by Ron Perlman
There are at least 10 aliens Marcus can shapeshift into. The following aliens are listed below.
Lazarus follows the story of Marcus Jones, a brilliant high schooler with a gift for the extreme. But when an Omnitrix crash lands in his world, his life changes as he finds out not only there are aliens in the far regions away from the galaxy, but there are much greater threats.
- Lazarus is named after the David Bowie song of the same name.
- The humour was inspired by the original Ben 10 series.