Helen appears with Manny, where the two had been sending aliens to the Null Void, thinking they were DNAliens and that they were killing them. They had accidentally sent Pierce there. John, Gwen and Kevin convince them that it isn't a death ray. Afterwards, the two travel into the Null Void to find Pierce.
When Animo takes over the Null Void, they call on John's help to stop him. They have found Pierce, and working under Wes to stop Animo. John succeeds in defeating Animo, and takes him away. They return with Wes during the final battle with the Highbreed, Wes taking them, Kai and Yenal to train to join the Plumbers.
The Plumbers Helpers get a mission to a satellite, to find Wes. There, they have to fight John, who's acting on orders to fight them. While Manny is defeated alone, together they all manage to defeat him.
They all eventually become Plumbers, when Pierce is killed by the Forever Knights. Manny goes on a revenge mission to take them out, John managing to get him to calm down. Together, they fight off the Knights. He later assists in the final battle against the Esoterica.
Her next appearance is during the Clone Wars, where she, Wes, Kai, Manny and Yenal go to Kylmyys, to negotiate a peace treaty with the leader, Kryptal. However, he's gone power mad, and almost gets them killed. They are saved in secret by Ultimate John. Afterwards, they manage to arrest Kryptal.
Their return, along with Pierce, was when Wes went to Coruscant for a Magister's conference. The planet is attacked by the Intellectuary and the Incurseans. The Intellectuary kills Wes, which sends Manny into a rage. Helen, Pierce and Yenal escort Kai away, who is in shock from Wes' death. She challenges Intellectuary after Manny's, Yenal's and Pierce's defeat in an attempt to allow Kai to escape. She is defeated and captured.
Helen appears as a member of the Rooters. Here, she poses as Argit's secretary to get inside info, which is used against him in court. She later appears with the entirety of the Rooters to attack Argit, though they all retreat.
Helen appears with Manny and Pierce, who work for Mecha at Mecha's Mechanics. They tried to rob him, but get their butts kicked. He makes them work for him.
Helen, Manny and Pierce take the term "Plumbers' Helpers as they hunt down criminals in Undertown. They are captured by the Rooters, and joins them after remembering their past.